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Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

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For example, dissolvable poly (-glutamic acid) microneedles co-loaded with EGCG and L-ascorbic acid retained 95% EGCG and 93% antioxidant activity after 4 weeks at 4 C, and delivered 63% EGCG and 62% ascorbic acid up to 600 m into the skin